Major clinical research advances in gynecologic cancer in 2015
Identifieur interne : 000E28 ( Main/Exploration ); précédent : 000E27; suivant : 000E29Major clinical research advances in gynecologic cancer in 2015
Auteurs : Dong Hoon Suh [Corée du Sud] ; Miseon Kim [Corée du Sud] ; Hak Jae Kim [Corée du Sud] ; Kyung-Hun Lee [Corée du Sud] ; Jae-Weon Kim [Corée du Sud]Source :
- Journal of Gynecologic Oncology [ 2005-0380 ] ; 2016.
Abstract
In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7–9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review.
Url:
DOI: 10.3802/jgo.2016.27.e53
PubMed: 27775259
PubMed Central: 5078817
Affiliations:
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strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Miseon" sort="Kim, Miseon" uniqKey="Kim M" first="Miseon" last="Kim">Miseon Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Hak Jae" sort="Kim, Hak Jae" uniqKey="Kim H" first="Hak Jae" last="Kim">Hak Jae Kim</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Radiation Oncology, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Internal Medicine, Seoul National University Hospital, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Jae Weon" sort="Kim, Jae Weon" uniqKey="Kim J" first="Jae-Weon" last="Kim">Jae-Weon Kim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul,<country>Korea</country>.</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Gynecologic Oncology</title><idno type="ISSN">2005-0380</idno><idno type="eISSN">2005-0399</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In 2015, fourteen topics were selected as major research advances in gynecologic oncology. For ovarian cancer, high-level evidence for annual screening with multimodal strategy which could reduce ovarian cancer deaths was reported. The best preventive strategies with current status of evidence level were also summarized. Final report of chemotherapy or upfront surgery (CHORUS) trial of neoadjuvant chemotherapy in advanced stage ovarian cancer and individualized therapy based on gene characteristics followed. There was no sign of abating in great interest in immunotherapy as well as targeted therapies in various gynecologic cancers. The fifth Ovarian Cancer Consensus Conference which was held in November 7–9 in Tokyo was briefly introduced. For cervical cancer, update of human papillomavirus vaccines regarding two-dose regimen, 9-valent vaccine, and therapeutic vaccine was reviewed. For corpus cancer, the safety concern of power morcellation in presumed fibroids was explored again with regard to age and prevalence of corpus malignancy. Hormone therapy and endometrial cancer risk, trabectedin as an option for leiomyosarcoma, endometrial cancer and Lynch syndrome, and the radiation therapy guidelines were also discussed. In addition, adjuvant therapy in vulvar cancer and the updated of targeted therapy in gynecologic cancer were addressed. For breast cancer, palbociclib in hormone-receptor-positive advanced disease, oncotype DX Recurrence Score in low-risk patients, regional nodal irradiation to internal mammary, supraclavicular, and axillary lymph nodes, and cavity shave margins were summarized as the last topics covered in this review.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Buys, Ss" uniqKey="Buys S">SS Buys</name></author><author><name sortKey="Partridge, E" uniqKey="Partridge E">E Partridge</name></author><author><name sortKey="Black, A" uniqKey="Black A">A Black</name></author><author><name sortKey="Johnson, Cc" uniqKey="Johnson C">CC Johnson</name></author><author><name sortKey="Lamerato, L" uniqKey="Lamerato L">L Lamerato</name></author><author><name sortKey="Isaacs, C" uniqKey="Isaacs C">C Isaacs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, Ij" uniqKey="Jacobs I">IJ Jacobs</name></author><author><name 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Kirkove</name></author><author><name sortKey="Van Limbergen, E" uniqKey="Van Limbergen E">E Van Limbergen</name></author><author><name sortKey="Budach, V" uniqKey="Budach V">V Budach</name></author><author><name sortKey="Struikmans, H" uniqKey="Struikmans H">H Struikmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chagpar, Ab" uniqKey="Chagpar A">AB Chagpar</name></author><author><name sortKey="Killelea, Bk" uniqKey="Killelea B">BK Killelea</name></author><author><name sortKey="Tsangaris, Tn" uniqKey="Tsangaris T">TN Tsangaris</name></author><author><name sortKey="Butler, M" uniqKey="Butler M">M Butler</name></author><author><name sortKey="Stavris, K" uniqKey="Stavris K">K Stavris</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Suh, Dong Hoon" sort="Suh, Dong Hoon" uniqKey="Suh D" first="Dong Hoon" last="Suh">Dong Hoon Suh</name></noRegion><name sortKey="Kim, Hak Jae" sort="Kim, Hak Jae" uniqKey="Kim H" first="Hak Jae" last="Kim">Hak Jae Kim</name><name sortKey="Kim, Jae Weon" sort="Kim, Jae Weon" uniqKey="Kim J" first="Jae-Weon" last="Kim">Jae-Weon Kim</name><name sortKey="Kim, Miseon" sort="Kim, Miseon" uniqKey="Kim M" first="Miseon" last="Kim">Miseon Kim</name><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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